Autoantibodies in Systemic Autoimmune Disorders

Autoantibodies in Systemic Autoimmune Disorders

1 INOVA Diagnostics, Inc., 9900 Old Grove Road, San Diego, CA 92131-1638, USA 2Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA 3 Laboratorio di Ricerche in Immunoreumatologia, Università di Milano, Istituto Auxologico Italiano, 20095 Cusano Milanino, Italy 4 Faculty of Medicine, ...

Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases.

EUKEMIA B CELLS from patients with chronic lymL phocytic leukemia (CLL) often make autoantibodies. Early studies by Preud'homme and Seligmann' showed that the leukemic cells from CLL patients often bear surface IgM (sIgM) that has rheumatoid factor (RF) activity, or binding activity for the Fc portion of human IgG. In another limited survey, the CLL cells from 4 of 13 patients (3 1 %) expressed...

Molecules in Systemic Autoimmune Diseases Autoantibodies to T Cell Costimulatory

Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity.

In this Review we focus on the initiation of autoantibody production and autoantibody pathogenicity, with a special emphasis on the targeted antigens. Release of intracellular antigens due to excessive cell death or to ineffective clearance of apoptotic debris, modification of self-antigens during inflammatory responses, and molecular mimicry contribute to the initiation of autoantibody product...

Autoantibodies in systemic autoimmune diseases : specificity and pathogenicity

Introduction The first autoantibodies were discovered in the late 1940s, when both antinuclear antibodies (ANAs) and rheumatoid factors (RFs) were described as serum factors that could bind nuclear antigens and immunoglobulins, respectively (1, 2). ANA and RF were recognized as diagnostic features of systemic lupus erythematosus (SLE) or RA, respectively, and as contributors to disease pathogen...